The effect of multiple genetic variants in predicting the risk of type 2 diabetes.

ABSTRACT: While recently performed genome-wide association studies have advanced the identification of genetic variants predisposing to type 2 diabetes (T2D), the potential application of these novel findings for disease prediction and prevention has not been well studied. Diabetes prediction and prevention have become urgent issues owing to the rapidly increasing prevalence of diabetes and its associated mortality, morbidity, and health care cost. New prediction approaches using genetic markers could facilitate early identification of high risk sub-groups of the population so that appropriate prevention methods could be effectively applied to delay, or even prevent, disease onset.This paper assessed 18 recently identified T2D loci for their potential role in diabetes prediction. We built a new pred

SUBMITTER: Lu Q 

PROVIDER: S-EPMC2795948 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature