Sequence and expression of the zebrafish alpha-actinin gene family reveals conservation and diversification among vertebrates.

ABSTRACT: Alpha-actinins are actin microfilament crosslinking proteins. Vertebrate actinins fall into two classes: the broadly-expressed actinins 1 and 4 (actn1 and actn4) and muscle-specific actinins, actn2 and actn3. Members of this family have numerous roles, including regulation of cell adhesion, cell differentiation, directed cell motility, intracellular signaling, and stabilization of f-actin at the sarcomeric Z-line in muscle. Here we identify five zebrafish actinin genes including two paralogs of ACTN3. We describe the temporal and spatial expression patterns of these genes through embryonic development. All zebrafish actinin genes have unique expression profiles, indicating specialization of each gene. In particular, the muscle actinins display preferential expression in different domains o

SUBMITTER: Holterhoff CK 

PROVIDER: S-EPMC2796163 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature