Structural basis of chemokine sequestration by a tick chemokine binding protein: the crystal structure of the complex between Evasin-1 and CCL3.

ABSTRACT:

Background

Chemokines are a subset of cytokines responsible for controlling the cellular migration of inflammatory cells through interaction with seven transmembrane G protein-coupled receptors. The blocking of a chemokine-receptor interaction results in a reduced inflammatory response, and represents a possible anti-inflammatory strategy, a strategy that is already employed by some virus and parasites. Anti-chemokine activity has been described in the extracts of tick salivary glands, and we have recently described the cloning and characterization of such chemokine binding proteins from the salivary glands, which we have named Evasins.

Methodology/principal findings

We have solved the structure of Evasin-1, a very small and highly selective chemokine-binding protein, by x-r

SUBMITTER: Dias JM 

PROVIDER: S-EPMC2796168 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature