Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue.

ABSTRACT: Historical data have indicated the potential for the histologically-normal breast to harbor pre-malignant changes at the molecular level. We postulated that a histologically-normal tissue with "tumor-like" gene expression pattern might harbor substantial risk for future cancer development. Genes associated with these high-risk tissues were considered to be "malignancy-risk genes". From a total of 90 breast cancer patients, we collected a set of 143 histologically-normal breast tissues derived from patients harboring breast cancer who underwent curative mastectomy, as well as a set of 42 invasive ductal carcinomas (IDC) of various histologic grades. All samples were assessed for global gene expression differences using microarray analysis. For the purpose of this study we defined normal bre

SUBMITTER: Chen DT 

PROVIDER: S-EPMC2796276 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature