Evaluating cumulative organophosphorus pesticide body burden of children: a national case study.

ABSTRACT: Biomonitoring is a valuable tool for identifying exposures to chemicals that pose potential harm to human health. However, to date there has been little published on ways to evaluate the relative public health significance of biomonitoring data for different chemicals and even less on cumulative assessment of multiple chemicals. The objectives of our study are to develop a methodology for a health risk interpretation of biomonitoring data and to apply it using NHANES 1999-2002 body burden data fororganophosphorus (OP) pesticides. OP pesticides present a particularly challenging case given the nonspecificity of manymetabolites monitored through NHANES. We back-calculate OP pesticide exposures from urinary metabolite data and compare cumulative dose estimates with available toxicity informat

SUBMITTER: Payne-Sturges D 

PROVIDER: S-EPMC2796428 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature