Significance of perihematomal edema in acute intracerebral hemorrhage: the INTERACT trial.

ABSTRACT:

Background

Uncertainty surrounds the effects of cerebral edema on outcomes in intracerebral hemorrhage (ICH).

Methods

We used data from the INTERACT trial to determine the predictors and prognostic significance of "perihematomal" edema over 72 hours after ICH. INTERACT included 404 patients with CT-confirmed ICH and elevated systolic blood pressure (BP) (150-220 mm Hg) who had the capacity to commence BP lowering treatment within 6 hours of ICH. Baseline and repeat CT (24 and 72 hours) were performed using standardized techniques, with digital images analyzed centrally. Predictors of growth in edema were determined using generalized estimating equations, and its effects on clinical outcomes were estimated using a logistic regression model.

Results

Overall, 270 patient

SUBMITTER: Arima H 

PROVIDER: S-EPMC2796457 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature