Association of vitamin D receptor polymorphisms with the risk of prostate cancer in the Han population of Southern China.

ABSTRACT:

Background

Molecular epidemiological studies have shown that gene polymorphisms of vitamin D receptor (VDR) are associated with prostate cancer risks. However, previous results from many molecular studies remain inconsistent.

Methods

Blood samples were collected from 122 prostate cancer patients and 130 age-matched control subjects in the Han population of Southern China. The differences of VDR gene polymorphism between cancer cases and controls were determined by PCR-RFLP, examiming FokI (exon 2), BsmI, Tru9I, ApaI (intron 9), and TaqI (exon 9). Associations between the VDR gene polymorphism and prostate cancer risk were calculated in an unconditional logistic regression model. Linkage disequilibrium and haplotypes were analyzed with the SHEsis software.

Results

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SUBMITTER: Bai Y 

PROVIDER: S-EPMC2796660 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature