The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function.

ABSTRACT: The Drosophila smooth gene encodes an RNA binding protein that has been well conserved through evolution. To investigate the pleiotropic functions mediated by the smooth gene, we have selected and characterized two sm mutants, which are viable as adults yet display robust phenotypes (including a significant decrease in lifespan). Utilizing these mutants, we have made the novel observation that disruption of the smooth/CG9218 locus leads to age-dependent muscle degeneration, and motor dysfunction. Histological characterization of adult sm mutants revealed marked abnormalities in the major thoracic tubular muscle: the tergal depressor of the trochanter (TDT). Corresponding defects include extensive loss/disruption of striations and nuclei. These pathological changes are recapitulated in flie

SUBMITTER: Draper I 

PROVIDER: S-EPMC2796714 | biostudies-literature | 2009 Oct-Dec

REPOSITORIES: biostudies-literature