Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium.

ABSTRACT:

Background

A greater reduction in cardiovascular risk and vascular protection associated with diet rich in polyphenols are generally accepted; however, the molecular targets for polyphenols effects remain unknown. Meanwhile evidences in the literature have enlightened, not only structural similarities between estrogens and polyphenols known as phytoestrogens, but also in their vascular effects. We hypothesized that alpha isoform of estrogen receptor (ERalpha) could be involved in the transduction of the vascular benefits of polyphenols.

Methodology/principal findings

Here, we used ERalpha deficient mice to show that endothelium-dependent vasorelaxation induced either by red wine polyphenol extract, Provinols, or delphinidin, an anthocyanin that possesses similar pharmacologi

SUBMITTER: Chalopin M 

PROVIDER: S-EPMC2796721 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature