Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice.

ABSTRACT:

Rationale

Epidemiologic studies implicate air pollutant exposure during pregnancy as a risk factor for wheezing in offspring. Ozone exposure is linked to exacerbations of wheezing in children.

Objectives

To determine if maternal pulmonary exposure to traffic-related particles during pregnancy augments ozone-induced airway hyperresponsiveness in offspring.

Methods

C57BL6 time-mated mice were given NIST SRM#1648 (particulate matter [PM]) 0.48 mg, saline vehicle, or no treatment by tracheal insufflation twice weekly for 3 weeks. PM exposure augmented maternal lung inflammation and placental TNF-alpha, Keratinocyte-derived cytokine (KC), and IL-6 (measured at gestation Day 18). After parturition, dams and litters were exposed to air or ozone 1 ppm 3 h/d, every other day,

SUBMITTER: Auten RL 

PROVIDER: S-EPMC2796733 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature