GATE: software for the analysis and visualization of high-dimensional time series expression data.

ABSTRACT:

Summary

We present Grid Analysis of Time series Expression (GATE), an integrated computational software platform for the analysis and visualization of high-dimensional biomolecular time series. GATE uses a correlation-based clustering algorithm to arrange molecular time series on a two-dimensional hexagonal array and dynamically colors individual hexagons according to the expression level of the molecular component to which they are assigned, to create animated movies of systems-level molecular regulatory dynamics. In order to infer potential regulatory control mechanisms from patterns of correlation, GATE also allows interactive interroga-tion of movies against a wide variety of prior knowledge datasets. GATE movies can be paused and are interactive, allowing users to reconstruct

SUBMITTER: MacArthur BD 

PROVIDER: S-EPMC2796822 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature