Direct control of mitochondrial function by mTOR.
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ABSTRACT:
SUBMITTER: Ramanathan A
PROVIDER: S-EPMC2796909 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Direct control of mitochondrial function by mTOR.
Ramanathan Arvind A Schreiber Stuart L SL
Proceedings of the National Academy of Sciences of the United States of America 20091222 52
mTOR is a central regulator of cellular growth and metabolism. Using metabolic profiling and numerous small-molecule probes, we investigated whether mTOR affects immediate control over cellular metabolism by posttranslational mechanisms. Inhibiting the FKBP12/rapamycin-sensitive subset of mTOR functions in leukemic cells enhanced aerobic glycolysis and decreased uncoupled mitochondrial respiration within 25 min. mTOR is in a complex with the mitochondrial outer-membrane protein Bcl-xl and VDAC1. ...[more]
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