The MED12-MED13 module of Mediator regulates the timing of embryo patterning in Arabidopsis.

ABSTRACT: The Arabidopsis embryo becomes patterned into central and peripheral domains during the first few days after fertilization. A screen for mutants that affect this process identified two genes, GRAND CENTRAL (GCT)and CENTER CITY (CCT). Mutations in GCT and CCT delay the specification of central and peripheral identity and the globular-to-heart transition, but have little or no effect on the initial growth rate of the embryo. Mutant embryos eventually recover and undergo relatively normal patterning, albeit at an inappropriate size. GCT and CCT were identified as the Arabidopsis orthologs of MED13 and MED12 - evolutionarily conserved proteins that act in association with the Mediator complex to negatively regulate transcription. The predicted function of these proteins combined with the effec

SUBMITTER: Gillmor CS 

PROVIDER: S-EPMC2796935 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature