Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro.

ABSTRACT:

Background

The neocortex is the most common target of subdural electrotherapy and noninvasive brain stimulation modalities, including transcranial magnetic stimulation (TMS) and transcranial current simulation (TCS). Specific neuronal elements targeted by cortical stimulation are considered to underlie therapeutic effects, but the exact cell type(s) affected by these methods remains poorly understood.

Objective

We determined whether neuronal morphology or cell type predicted responses to subthreshold and suprathreshold uniform electric fields.

Methods

We characterized the effects of subthreshold and suprathreshold electrical stimulation on identified cortical neurons in vitro. Uniform electric fields were applied to rat motor cortex brain slices, while recording from

SUBMITTER: Radman T 

PROVIDER: S-EPMC2797131 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature