Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer.

ABSTRACT: The phosphatidylinositol 3-kinase (PI3K) pathway is a critical signal transduction pathway that regulates multiple cellular functions. Aberrant activation of this pathway has been identified in a wide range of cancers. Several pathway components including AKT, PI3K and mTOR represent potential therapeutic targets and many small molecule inhibitors are in development or early clinical trials. The complex regulation of the pathway, together with the multiple mechanisms by which it can be activated, make this a highly challenging pathway to target. For successful inhibition, detailed molecular information on individual tumours will be required and it is already clear that different tumour types show distinct combinations of alterations. Recent results have identified alterations in pathway co

SUBMITTER: Knowles MA 

PROVIDER: S-EPMC2797439 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature