The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924.

ABSTRACT:

Background

Common FTO (fat mass and obesity associated) gene variants have recently been strongly associated with body mass index and obesity in several large studies. Here we set out to examine the association of the FTO variant rs9939609 with BMI in a 32 year follow up study of men born 1920-1924. Moreover, we analyzed the effect of physical activity on the different genotypes.

Methods

The FTO rs9936609 was genotyped using an Illumina golden gate assay. BMI was calculated using standard methods and body fat was estimated by measuring skinfold thickness using a Harpenden caliper. Physical activity was assessed using a four question medical questionnaire.

Results

FTO rs9939609 was genotyped in 1153 elderly Swedish men taking part of a population-based cohort study, th

SUBMITTER: Jacobsson JA 

PROVIDER: S-EPMC2797506 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature