Transcriptomic analysis of human lung development.

ABSTRACT:

Rationale

Current understanding of the molecular regulation of lung development is limited and derives mostly from animal studies.

Objectives

To define global patterns of gene expression during human lung development.

Methods

Genome-wide expression profiling was used to measure the developing lung transcriptome in RNA samples derived from 38 normal human lung tissues at 53 to 154 days post conception. Principal component analysis was used to characterize global expression variation and to identify genes and bioontologic attributes contributing to these variations. Individual gene expression patterns were verified by quantitative reverse transcriptase-polymerase chain reaction analysis.

Measurements and main results

Gene expression analysis identified attributes

SUBMITTER: Kho AT 

PROVIDER: S-EPMC2797628 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature