Evaluation of quantitative IFN-gamma response for risk stratification of active tuberculosis suspects.

ABSTRACT:

Rationale

The contribution of interferon-gamma release assays (IGRAs) to appropriate risk stratification of active tuberculosis suspects has not been studied.

Objectives

To determine whether the addition of quantitative IGRA results to a prediction model incorporating clinical criteria improves risk stratification of smear-negative-tuberculosis suspects.

Methods

Clinical data from tuberculosis suspects evaluated by the San Francisco Department of Public Health Tuberculosis Control Clinic from March 2005 to February 2008 were reviewed. We excluded tuberculosis suspects who were acid fast-bacilli smear-positive, HIV-infected, or under 10 years of age. We developed a clinical prediction model for culture-positive disease and examined the benefit of adding quantitative in

SUBMITTER: Metcalfe JZ 

PROVIDER: S-EPMC2797629 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature