Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer.

ABSTRACT:

Aim

To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.

Methods

Genomic DNA was extracted from paraffin-embedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals. Allelic discrimination was performed by quantitative real-time polymerase chain reaction. Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.

Results

Thirty-nine (32%) patients displayed a CC genotype, 57 (46.7%) a CT genotype and 26 (21.3%) a TT genotype. The frequency of the C allele (fC) in the patient group was 0.55, which was not significantly different from tha

SUBMITTER: Alakus H 

PROVIDER: S-EPMC2797662 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature