DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort.

ABSTRACT:

Background

As dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been implicated in the abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for AD.

Methods

We examined genetic variations of DYRK1A by genotyping haplotype tagging SNPs (htSNPs) (rs11701483, rs2835740, rs1137600, rs2835761, rs2835762, rs2154545 and rs8132976) in a group of 634 Spanish AD cases and 733 controls.

Results

There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by APOE epsilon4 allele.

Conclusion

Our negative findings in the Spanish p

SUBMITTER: Vazquez-Higuera JL 

PROVIDER: S-EPMC2797783 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature