Exploring complex miRNA-mRNA interactions with Bayesian networks by splitting-averaging strategy.

ABSTRACT:

Background

microRNAs (miRNAs) regulate target gene expression by controlling their mRNAs post-transcriptionally. Increasing evidence demonstrates that miRNAs play important roles in various biological processes. However, the functions and precise regulatory mechanisms of most miRNAs remain elusive. Current research suggests that miRNA regulatory modules are complicated, including up-, down-, and mix-regulation for different physiological conditions. Previous computational approaches for discovering miRNA-mRNA interactions focus only on down-regulatory modules. In this work, we present a method to capture complex miRNA-mRNA interactions including all regulatory types between miRNAs and mRNAs.

Results

We present a method to capture complex miRNA-mRNA interactions using Bayesia

SUBMITTER: Liu B 

PROVIDER: S-EPMC2797807 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature