Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy.

ABSTRACT:

Objective

The severity of peripheral neuropathy in diabetic patients varies for unclear reasons. Long-term use of metformin is associated with malabsorption of vitamin B(12) (cobalamin [Cbl]) and elevated homocysteine (Hcy) and methylmalonic acid (MMA) levels, which may have deleterious effects on peripheral nerves. The intent of this study was to clarify the relationship among metformin exposure, levels of Cbl, Hcy, and MMA, and severity of peripheral neuropathy in diabetic patients. We hypothesized that metformin exposure would be associated with lower Cbl levels, elevated Hcy and MMA levels, and more severe peripheral neuropathy.

Research design and methods

This was a prospective case-control study of patients with type 2 diabetes and concurrent symptomatic peripheral neu

SUBMITTER: Wile DJ 

PROVIDER: S-EPMC2797962 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature