Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic.

ABSTRACT: The immune correlates of human/simian immunodeficiency virus control remain elusive. While CD8(+) T lymphocytes likely play a major role in reducing peak viremia and maintaining viral control in the chronic phase, the relative antiviral efficacy of individual virus-specific effector populations is unknown. Conventional assays measure cytokine secretion of virus-specific CD8(+) T cells after cognate peptide recognition. Cytokine secretion, however, does not always directly translate into antiviral efficacy. Recently developed suppression assays assess the efficiency of virus-specific CD8(+) T cells to control viral replication, but these assays often use cell lines or clones. We therefore designed a novel virus production assay to test the ability of freshly ex vivo-sorted simian immunodefi

SUBMITTER: Vojnov L 

PROVIDER: S-EPMC2798340 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature