Envelope vaccination shapes viral envelope evolution following simian immunodeficiency virus infection in rhesus monkeys.

ABSTRACT: The evolution of envelope mutations by replicating primate immunodeficiency viruses allows these viruses to escape from the immune pressure mediated by neutralizing antibodies. Vaccine-induced anti-envelope antibody responses may accelerate and/or alter the specificity of the antibodies, thus shaping the evolution of envelope mutations in the replicating virus. To explore this possibility, we studied the neutralizing antibody response and the envelope sequences in rhesus monkeys vaccinated with either gag-pol-nef immunogens or gag-pol-nef immunogens in combination with env and then infected with simian immunodeficiency virus (SIV). Using a pseudovirion neutralization assay, we demonstrate that envelope vaccination primed for an accelerated neutralizing antibody response following virus cha

SUBMITTER: Basavapathruni A 

PROVIDER: S-EPMC2798359 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature