Role of nuclear factor Y in stress-induced activation of the herpes simplex virus type 1 ICP0 promoter.

ABSTRACT: Herpesviruses are characterized by the ability to establish lifelong latent infections and to reactivate periodically, leading to recurrent disease. The herpes simplex virus type 1 (HSV-1) genome is maintained in a quiescent state in sensory neurons during latency, which is characterized by the absence of detectable viral protein synthesis. Cellular factors induced by stress may act directly on promoters within the latent viral genome to induce the transcription of viral genes and trigger reactivation. In order to identify which viral promoters are induced by stress and elucidate the cellular mechanism responsible for the induction, we generated a panel of HSV-1 promoter-luciferase constructs and measured their response to heat shock. Of the promoters tested, those of ICP0 and ICP22 were t

SUBMITTER: Kushnir AS 

PROVIDER: S-EPMC2798407 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature