Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency.

ABSTRACT:

Background

Activation of bradykinin-mediated B2 receptor has been shown to play an important role in the onset of angioedema associated with C1 inhibitor deficiency. This finding has led to the development of novel therapeutic drugs such as the B2 receptor antagonist icatibant. However, it is unclear whether other receptors expressed on endothelial cells contribute to the release of kinins and vascular leakage in these patients. The recognition of their role may have obvious therapeutic implications.

Objective

Our aim was to investigate the involvement of B1 and gC1q receptors in in vitro and in vivo models of vascular leakage induced by plasma samples obtained from patients with C1 inhibitor deficiency.

Methods

The vascular leakage was evaluated in vitro on endotheli

SUBMITTER: Bossi F 

PROVIDER: S-EPMC2798851 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature