P-Cresyl sulfate and indoxyl sulfate in hemodialysis patients.

ABSTRACT:

Background and objectives

Indoxyl sulfate and p-cresyl sulfate are important representatives of the protein-bound uremic retention solutes. Serum levels of p-cresyl sulfate and indoxyl sulfate are linked to cardiovascular outcomes and chronic kidney disease progression, respectively. They share important features such as the albumin-binding site, low dialytic clearance, and both originate from protein fermentation. Whether serum concentrations are related is, however, not known.

Design, setting, participants, & measurements

In an observational study in 75 maintenance hemodialysis patients, we studied agreement between indoxyl sulfate and p-cresyl sulfate serum concentrations, dialytic reduction rates, and dialytic clearances. Concentrations were determined by HPLC. Dialytic

SUBMITTER: Meijers BK 

PROVIDER: S-EPMC2798868 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature