Efficient synthesis of fluorescent squaraine rotaxane dendrimers.

ABSTRACT: A squaraine rotaxane scaffold with four alkyne groups is readily converted into a range of dendritic architectures using high-yielding copper-catalyzed alkyne azide cycloaddition (CuAAC) chemistry. A convergent synthesis approach is more efficient than a divergent pathway. Dendritic squaraine rotaxanes with peripheral amine groups can be further functionalized to produce multivalent deep-red fluorescent derivatives that exhibit high brightness and outstanding chemical stability in biological solution. The surface groups on these functionalized fluorescent dendrimers include guanidinium, mannose, and phosphatidylcholine.

SUBMITTER: Xiao S 

PROVIDER: S-EPMC2798916 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature