Gene expression in a Drosophila model of mitochondrial disease.

ABSTRACT:

Background

A point mutation in the Drosophila gene technical knockout (tko), encoding mitoribosomal protein S12, was previously shown to cause a phenotype of respiratory chain deficiency, developmental delay, and neurological abnormalities similar to those presented in many human mitochondrial disorders, as well as defective courtship behavior.

Methodology/principal findings

Here, we describe a transcriptome-wide analysis of gene expression in tko(25t) mutant flies that revealed systematic and compensatory changes in the expression of genes connected with metabolism, including up-regulation of lactate dehydrogenase and of many genes involved in the catabolism of fats and proteins, and various anaplerotic pathways. Gut-specific enzymes involved in the primary mobilization of

SUBMITTER: Fernandez-Ayala DJ 

PROVIDER: S-EPMC2798955 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature