Dissecting the dynamics of dysregulation of cellular processes in mouse mammary gland tumor.

ABSTRACT:

Background

Elucidating the sequence of molecular events underlying breast cancer formation is of enormous value for understanding this disease and for design of an effective treatment. Gene expression measurements have enabled the study of transcriptome-wide changes involved in tumorigenesis. This usually occurs through identification of differentially expressed genes or pathways.

Results

We propose a novel approach that is able to delineate new cancer-related cellular processes and the nature of their involvement in tumorigenesis. First, we define modules as densely interconnected and functionally enriched areas of a Protein Interaction Network. Second, 'differential expression' and 'differential co-expression' analyses are applied to the genes in these network modules, all

SUBMITTER: Mentzen WI 

PROVIDER: S-EPMC2799442 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature