Insights into distinct regulatory modes of nucleosome positioning.

ABSTRACT:

Background

The nucleosome is the fundamental unit of eukaryotic genomes. Experimental evidence suggests that the genomic DNA sequence and a variety of protein factors contribute to nucleosome positioning in vivo. However, how nucleosome positioning is determined locally is still largely unknown.

Results

We found that transcription factor binding sites (TFBSs) with particular nucleosomal contexts show a preference to reside on specific chromosomes. We identified four typical gene classes associated with distinct regulatory modes of nucleosome positioning, and further showed that they are distinguished by transcriptional regulation patterns. The first mode involves the cooperativity between chromatin remodeling and stable transcription factor (TF)-DNA binding that is linked to

SUBMITTER: Dai Z 

PROVIDER: S-EPMC2799443 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature