Regulation of Emx2 expression by antisense transcripts in murine cortico-cerebral precursors.

ABSTRACT:

Background

Emx2 encodes for a transcription factor expressed in the embryonic intermediate mesoderm and central nervous system (CNS). It is implicated in several aspects of cerebral cortex development, including morphogenetic field specification, arealization, precursor proliferation and lamination. Four Emx2-associated antisense transcripts have been found in the urogenital system; one of them, Emx2OS, has been also detected in the adult brain. Until now, however, nothing is known about expression and function of Emx2OS in the developing CNS.

Methodology/principal findings

By quantitative RT-PCR and in situ hybridization, we reconstructed the Emx2OS expression profile in the embryonic CNS, paying special attention to the developing cerebral cortex. Emx2OS was observed in a

SUBMITTER: Spigoni G 

PROVIDER: S-EPMC2799550 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature