Tbx4/5 gene duplication and the origin of vertebrate paired appendages.

ABSTRACT: Paired fins/limbs are one of the most successful vertebrate innovations, since they are used for numerous fundamental activities, including locomotion, feeding, and breeding. Gene duplication events generate new genes with the potential to acquire novel functions, and two rounds of genome duplication took place during vertebrate evolution. The cephalochordate amphioxus diverged from other chordates before these events and is widely used to deduce the functions of ancestral genes, present in single copy in amphioxus, compared to the functions of their duplicated vertebrate orthologues. The T-box genes Tbx5 and Tbx4 encode two closely related transcription factors that are the earliest factors required to initiate forelimb and hind limb outgrowth, respectively. Since the genetic components p

SUBMITTER: Minguillon C 

PROVIDER: S-EPMC2799857 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature