The importance of being flexible: the case of basic region leucine zipper transcriptional regulators.

ABSTRACT: Large volumes of protein sequence and structure data acquired by proteomic studies led to the development of computational bioinformatic techniques that made possible the functional annotation and structural characterization of proteins based on their primary structure. It has become evident from genome-wide analyses that many proteins in eukaryotic cells are either completely disordered or contain long unstructured regions that are crucial for their biological functions. The content of disorder increases with evolution indicating a possibly important role of disorder in the regulation of cellular systems. Transcription factors are no exception and several proteins of this class have recently been characterized as premolten/molten globules. Yet, mammalian cells rely on these proteins to co

SUBMITTER: Miller M 

PROVIDER: S-EPMC2800128 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature