Semiparametric estimation of the average causal effect of treatment on an outcome measured after a postrandomization event, with missing outcome data.

ABSTRACT: In the past decade, several principal stratification-based statistical methods have been developed for testing and estimation of a treatment effect on an outcome measured after a postrandomization event. Two examples are the evaluation of the effect of a cancer treatment on quality of life in subjects who remain alive and the evaluation of the effect of an HIV vaccine on viral load in subjects who acquire HIV infection. However, in general the developed methods have not addressed the issue of missing outcome data, and hence their validity relies on a missing completely at random (MCAR) assumption. Because in many applications the MCAR assumption is untenable, while a missing at random (MAR) assumption is defensible, we extend the semiparametric likelihood sensitivity analysis approach of G

SUBMITTER: Gilbert PB 

PROVIDER: S-EPMC2800161 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature