Beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC.

ABSTRACT: Gram-positive bacteria contain a family of surface proteins that are covalently anchored to the cell wall of the organism. These cell-wall anchored (CWA) proteins appear to play key roles in the interactions between pathogenic organisms and the host. A subfamily of the CWA has a common structural organization with multiple domains adopting characteristic IgG-like folds. The identified microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) belong to this subfamily, as does SdrC from S. aureus. However, an interactive host ligand for the putative MSCRAMM SdrC was not previously identified. We have screened a phage display peptide library and identified a peptide sequence found in beta-neurexin that binds SdrC. A synthetic peptide corresponding to the identified sequenc

SUBMITTER: Barbu EM 

PROVIDER: S-EPMC2800189 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature