Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina.

ABSTRACT: Development of therapies to treat visual system dystrophies resulting from the degeneration of rod and cone photoreceptors may directly benefit from studies of animal models, such as the zebrafish, that display continuous retinal neurogenesis and the capacity for injury-induced regeneration. Previous studies of retinal regeneration in fish have been conducted on adult animals and have relied on methods that cause acute damage to both rods and cones, as well as other retinal cell types. We report here the use of a genetic approach to study progenitor cell responses to photoreceptor degeneration in the larval and adult zebrafish retina. We have compared the responses to selective rod or cone degeneration using, respectively, the XOPS-mCFP transgenic line and zebrafish with a null mutation in

SUBMITTER: Morris AC 

PROVIDER: S-EPMC2801137 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature