Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.

ABSTRACT:

Background

Hypertension affects > 18.8% of adults in China. Indeed, hypertension is the most prevalent risk factor for cardiovascular morbidity and mortality worldwide. Genetic variation is thought to contribute to the etiology of hypertension. NEDD4L is a candidate gene for hypertension, both functionally and genetically. The purpose of the current study was to investigate the relationship between the variation in NEDD4L and essential hypertension in Kazakh, which is a relatively isolated population with a pure genetic background and is an ideal population to study genetic mechanisms of hypertension.

Methods

We screened the promoter and exons of NEDD4L in 94 Kazakh hypertensive individuals to identify representative variations. Then, by genotyping the representative variati

SUBMITTER: Li N 

PROVIDER: S-EPMC2801499 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature