The origin of bmp16, a novel Bmp2/4 relative, retained in teleost fish genomes.

ABSTRACT:

Background

Whole genome sequences have allowed us to have an overview of the evolution of gene repertoires. The target of the present study, the TGFbeta superfamily, contains many genes involved in vertebrate development, and provides an ideal system to explore the relationships between evolution of gene repertoires and that of developmental programs.

Results

As a result of a bioinformatic survey of sequenced vertebrate genomes, we identified an uncharacterized member of the TGFbeta superfamily, designated bmp16, which is confined to teleost fish species. Our molecular phylogenetic study revealed a high affinity of bmp16 to the Bmp2/4 subfamily. Importantly, further analyses based on the maximum-likelihood method unambiguously ruled out the possibility that this teleost-spec

SUBMITTER: Feiner N 

PROVIDER: S-EPMC2801517 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature