Comparison of antipsychotic medication effects on reducing violence in people with schizophrenia.

ABSTRACT:

Background

Violence is an uncommon but significant problem associated with schizophrenia.

Aims

To compare antipsychotic medications in reducing violence among patients with schizophrenia over 6 months, identify prospective predictors of violence and examine the impact of medication adherence on reduced violence.

Method

Participants (n=1445) were randomly assigned to double-blinded treatment with one of five antipsychotic medications. Analyses are presented for the intention-to-treat sample and for patients completing 6 months on assigned medication.

Results

Violence declined from 16% to 9% in the retained sample and from 19% to 14% in the intention-to-treat sample. No difference by medication group was found, except that perphenazine showed greater violence red

SUBMITTER: Swanson JW 

PROVIDER: S-EPMC2801826 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature