COL4A1 is associated with arterial stiffness by genome-wide association scan.

ABSTRACT:

Background

Pulse wave velocity (PWV), a noninvasive index of central arterial stiffness, is a potent predictor of cardiovascular mortality and morbidity. Heritability and linkage studies have pointed toward a genetic component affecting PWV. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with PWV.

Methods and results

The study cohort included participants from the SardiNIA study for whom PWV measures were available. Genotyping was performed in 4221 individuals, using either the Affymetrix 500K or the Affymetrix 10K mapping array sets (with imputation of the missing genotypes). Associations with PWV were evaluated using an additive genetic model that included age, age(2), and sex as covariates. The findings were test

SUBMITTER: Tarasov KV 

PROVIDER: S-EPMC2801872 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature