Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction.

ABSTRACT:

Aims

Previous studies suggested that androgens augmented renal vascular responses to angiotensin II (Ang II). The protein kinase C (PKC)-CPI-17 pathway is involved in vascular constriction. We tested the hypothesis that this pathway may contribute to androgenic amplification of Ang II-renal vasoconstriction in the New Zealand genetically hypertensive (NZGH) rat.

Methods and results

NZGH underwent sham operation, castration, or castration with testosterone replacement at 5 weeks of age. When the rats were 16-17 weeks of age, mean arterial pressure (MAP) and renal vascular resistance (RVR) responses to intravenous Ang II infusion (20, 40, and 80 ng/kg/min) were recorded before and after treatment with a PKC inhibitor, chelerythrine. mRNA expression of PKC isoforms and CPI-17 p

SUBMITTER: Song J 

PROVIDER: S-EPMC2802204 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature