Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.

ABSTRACT:

Purpose

Toll-like receptor 2 (TLR2) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands, and interacts with heat-shock proteins, which are reportedly involved in normal tension glaucoma (NTG). We investigated whether TLR2 polymorphisms are associated with NTG.

Methods

200 Japanese patients with NTG and 128 healthy Japanese controls were recruited. We genotyped five single-nucleotide polymorphisms (SNPs) in the TLR2 gene and assessed the allele and haplotype diversities between cases and controls for all SNPs.

Results

No significant differences in the frequency of TLR2 alleles and haplotypes in the NTG cases were detected, compared with the controls.

Conclusions

Our study showed no evidence for an association between TL

SUBMITTER: Nakamura J 

PROVIDER: S-EPMC2802293 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature