Pharmacogenomic discovery using cell-based models.

ABSTRACT: Quantitative variation in response to drugs in human populations is multifactorial; genetic factors probably contribute to a significant extent. Identification of the genetic contribution to drug response typically comes from clinical observations and use of classic genetic tools. These clinical studies are limited by our inability to control environmental factors in vivo and the difficulty of manipulating the in vivo system to evaluate biological changes. Recent progress in dissecting genetic contribution to natural variation in drug response through the use of cell lines has been made and is the focus of this review. A general overview of current cell-based models used in pharmacogenomic discovery and validation is included. Discussion includes the current approach to translate findings

SUBMITTER: Welsh M 

PROVIDER: S-EPMC2802425 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature