Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone.

ABSTRACT: The aryl hydrocarbon receptor (AHR) is regarded as an important homeostatic transcriptional regulator within physiological and pathophysiological processes, including xenobiotic metabolism, endocrine function, immunity, and cancer. Agonist activation of the AHR is considered deleterious based on toxicological evidence obtained with environmental pollutants, which mediate toxic effects through AHR. However, a multitude of plant-derived constituents, e.g., polyphenols that exhibit beneficial properties, have also been described as ligands for the AHR. It is conceivable that some of the positive aspects of such compounds can be attributed to suppression of AHR activity through antagonism. Therefore, we conducted a dioxin response element reporter-based screen to assess the AHR activity associ

SUBMITTER: Murray IA 

PROVIDER: S-EPMC2802483 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature