Comparison of gene expression during in vivo and in vitro postnatal retina development.

ABSTRACT:

Unlabelled

Retina explants are widely used as a model of neural development. To define the molecular basis of differences between the development of retina in vivo and in vitro during the early postnatal period, we carried out a series of microarray comparisons using mouse retinas. About 75% of 8,880 expressed genes from retina explants kept the same expression volume and pattern as the retina in vivo. Fewer than 6% of the total gene population was changed at two consecutive time points, and only about 1% genes showed more than a threefold change at any time point studied. Functional Gene Ontology (GO) mapping for both changed and unchanged genes showed similar distribution patterns, except that more genes were changed in the GO clusters of response to stimuli and carbohydrate meta

SUBMITTER: Liu MG 

PROVIDER: S-EPMC2802513 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature