Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

ABSTRACT:

Context

Plasma levels of C-reactive protein (CRP) are independently associated with risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain.

Objective

To investigate association of genetic loci with CRP levels and risk of coronary heart disease.

Design, setting, and participants

We first carried out a genome-wide association (n = 17,967) and replication study (n = 13,615) to identify genetic loci associated with plasma CRP concentrations. Data collection took place between 1989 and 2008 and genotyping between 2003 and 2008. We carried out a mendelian randomization study of the most closely associated single-nucleotide polymorphism (SNP) in the CRP locus and publish

SUBMITTER: Elliott P 

PROVIDER: S-EPMC2803020 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature