Phylogenomics of the oxidative phosphorylation in fungi reveals extensive gene duplication followed by functional divergence.

ABSTRACT:

Background

Oxidative phosphorylation is central to the energy metabolism of the cell. Due to adaptation to different life-styles and environments, fungal species have shaped their respiratory pathways in the course of evolution. To identify the main mechanisms behind the evolution of respiratory pathways, we conducted a phylogenomics survey of oxidative phosphorylation components in the genomes of sixty fungal species.

Results

Besides clarifying orthology and paralogy relationships among respiratory proteins, our results reveal three parallel losses of the entire complex I, two of which are coupled to duplications in alternative dehydrogenases. Duplications in respiratory proteins have been common, affecting 76% of the protein families surveyed. We detect several instances o

SUBMITTER: Marcet-Houben M 

PROVIDER: S-EPMC2803194 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature