Identification of ATP binding residues of a protein from its primary sequence.

ABSTRACT:

Background

One of the major challenges in post-genomic era is to provide functional annotations for large number of proteins arising from genome sequencing projects. The function of many proteins depends on their interaction with small molecules or ligands. ATP is one such important ligand that plays critical role as a coenzyme in the functionality of many proteins. There is a need to develop method for identifying ATP interacting residues in a ATP binding proteins (ABPs), in order to understand mechanism of protein-ligands interaction.

Results

We have compared the amino acid composition of ATP interacting and non-interacting regions of proteins and observed that certain residues are preferred for interaction with ATP. This study describes few models that have been developed

SUBMITTER: Chauhan JS 

PROVIDER: S-EPMC2803200 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature