Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.

ABSTRACT: Lower respiratory tract infection by the human pneumovirus respiratory syncytial virus is a frequent cause of acute lung injury in children. Severe pneumovirus disease in humans is associated with activation of the granzyme pathway by effector lymphocytes, which may promote pathology by exaggerating proapoptotic caspase activity and proinflammatory activity. The main goal of this study was to determine whether granzymes contribute to the development of acute lung injury in pneumovirus-infected mice. Granzyme-expressing mice and granzyme A- and B-cluster single- and double-knockout mice were inoculated with the rodent pneumovirus pneumonia virus of mice strain J3666, and were studied for markers of lung inflammation and injury. Expression of granzyme A and B is detected in effector lymphocy

SUBMITTER: Bem RA 

PROVIDER: S-EPMC2803336 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature